Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Cortisol → Hydrocortisone (4-chloro)butanoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Cortisol | HCID 5754 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 4-Chlorobutyryl chloride | HCID 78370 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 생성물 | Hydrocortisone (4-chloro)butanoate | HCID 86595714 | 53% |
반응 단계
4 portions of 4-chlorobutanoylchloride (0.32 ml×4) and triethylamine (0.3 g×4) were added in 24 hours to a solution of hydrocortisone (1 g) in CHCl3 dried over P2O5, and stirred for 3 days. The solution was treated with water, the organic phase was separated, dried (Na2SO4) and deprived of the solvent at reduced pressure. The crude residue was ground with hexane and CH2Cl2 to give a white solid with a 53% yield by weight, which had a melting point (m.p.) of 155° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06610676B1 |
| 출처 데이터셋 | uspto-grants-2003_08 |
| ORD ID | ord-01127625807d4126ba9a0a5612202df9 |
| 출처 메모 | uspto-grants-2003_08 |