Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Phosphorus oxychloride → 7H-Pyrrolo(2,3-d)pyrimidine, 4-chloro-
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Phosphorus oxychloride | HCID 24813 | — |
| 반응물 | 7-Deazahypoxanthine | HCID 135408689 | — |
| 생성물 | 7H-Pyrrolo(2,3-d)pyrimidine, 4-chloro- | HCID 5356682 | 70% |
반응 단계
3,7-Dihydro-pyrrolo[2,3-d]pyrimidin-4-one (60 mg, 0.45 mmol) was reacted with 3.0 mL of phosphorus oxychloride to give 49 mg (70%) of 4-chloro-7H-pyrrolo[2,3-d]pyrimidine as an off-white solid. 1H NMR (300 MHz, DMSO-d6) δ 12.57 (s, br, 1H, NH), 8.58 (s, 1H), 7.68 (dd, J=2.53, 3.36 Hz, 1H), and 6.59 (dd, J=1.86, 3.36 Hz, 1H). MS m/e 153 [M-1]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06610688B2 |
| 출처 데이터셋 | uspto-grants-2003_08 |
| ORD ID | ord-8a4a6721538743c284840252b706536b |
| 출처 메모 | uspto-grants-2003_08 |