Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyridine → N1-(4-Methoxybenzoyl)-N2-[4-(4-morpholinyl)benzyl]-1,2-benzenediamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | Phosgene | HCID 6371 | — |
| 반응물 | N-(2-Aminophenyl)-4-methoxybenzamide | HCID 785232 | — |
| 반응물 | [4-(Morpholin-4-yl)phenyl]methanol | HCID 2776456 | — |
| 용매 | Toluene | HCID 1140 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | N1-(4-Methoxybenzoyl)-N2-[4-(4-morpholinyl)benzyl]-1,2-benzenediamine | HCID 9844868 | 14% |
반응 단계
4-(4-Morpholinyl)benzyl alcohol (150 mg, 0.78 mmol) was added to a solution of phosgene in toluene (1.93 M, 1.2 mL). After 4 h, the mixture was treated with a solution of N1-(4-methoxybenzoyl)-1,2-benzenediamine (188 mg, 0.78 mmol) and pyridine (2 mL) in methylene chloride (3 mL). After 16 h, the mixture was concentrated and the residue was dissolved in EtOAc. The organic layer was washed with water (4×), brine (1×), dried with potassium carbonate, and concentrated. The residue was purified by chromatography (SiO2, 5 to 15% EtOAc in CH2Cl2), yielding 45 mg (14%) of the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06610704B1 |
| 출처 데이터셋 | uspto-grants-2003_08 |
| ORD ID | ord-8e63c8578ab04ca1b7d062c795c3e082 |
| 출처 메모 | uspto-grants-2003_08 |