참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 1,3-Propanediol, 2-methylene- | HCID 77048 | — |
| 반응물 | tert-Butyldiphenylchlorosilane | HCID 94078 | — |
| 촉매 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 2-t-Butyldiphenylsilyloxymethyl-2-propene-1-ol | HCID 11450232 | — |
반응 단계
A solution of t-butyldiphenylsilylchloride (45 g, 165 mmol) in anhydrous dichloromethane (60 ml) is added dropwise to a stirred solution of 2-hydroxymethyl-2-propene-1-ol (12 g, 165 mmol) triethylamine (27.5 ml) and 4-dimethylaminopyridine (2 g) in anhydrous dichloromethane (300 ml) at 0° C. Then, the mixture is stirred at 20° C. overnight, washed with a saturated solution of ammonium chloride and brine. The title product is obtained by flash chromatography on silica gel (19.4 g, 40%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US05817647 |
|---|
| 출처 데이터셋 | uspto-grants-1998_10 |
|---|
| ORD ID | ord-4344173e408d41da86afd0d513d3a6f7 |
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| 출처 메모 | uspto-grants-1998_10 |
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