참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Methyl morpholine oxide | HCID 82029 | — |
| 반응물 | 2-t-Butyldiphenylsilyloxymethyl-2-propene-1-ol | HCID 11450232 | — |
| 촉매 | HCID 178419074 | HCID 178419074 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 2-t-Butyldiphenylsilyloxymethyl-2-propenal | HCID 53309787 | 83% |
반응 단계
A mixture of 2-t-butyldiphenylsilyloxymethyl-2-propene-1-ol (25.5 g, 86.7 mmol), molecular sieves in powder (26 g), N-methylmorpholine-N-oxide (15.3 g, 130 mmol) and tetrapropylammoniumperruthenate (1.5 g, 4 mmol) in anhydrous dichloromethane (400 ml) is stirred overnight at 20° C. Then the reaction mixture is concentrated in vacuo and purified by flash chromatography on silica gel to give the title product (21 g, 83%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05817647 |
|---|
| 출처 데이터셋 | uspto-grants-1998_10 |
|---|
| ORD ID | ord-8661d624be634f08924ce746aaf0c6dc |
|---|
| 출처 메모 | uspto-grants-1998_10 |
|---|
