Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 3-Chloro-o-cresol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 1,3,3-Trichloro-2-methyl-7-oxabicyclo[4.1.0]heptane | HCID 18970971 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 3-Chloro-o-cresol | HCID 14856 | 89.2% |
반응 단계
2 g (9.28 mmol) of epoxide 2h in solution in 5 cm3 of anhydrous DMF were heated to reflux for 3 h. The solution was acidified (pH=1) with 3N HCl, extracted with ether (4×25 cm3), dried over MgSO4, filtered and evaporated down. The crude product obtained was purified by flash chromatography on silica (eluent: ether/petroleum ether=5/95). 1.18 g of phenol 4e were obtained (macrobore GC purity>96%). The yield of compound 4e was 89%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05817890 |
| 출처 데이터셋 | uspto-grants-1998_10 |
| ORD ID | ord-82f33f72dd9547d68c3b69b304db87fc |
| 출처 메모 | uspto-grants-1998_10 |