Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ammonia → HCID 178508933, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ammonia | HCID 222 | — |
| 반응물 | 2-((Acetyloxy)methoxy)ethyl acetate | HCID 100999 | — |
| 반응물 | Diacetylguanine | HCID 136360183 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 생성물 | HCID 178508933 | HCID 178508933 | — |
반응 단계
Matsumoto in Chem Pharm Bull, 36(3), 1153-1157 and JP 63-107982 teaches a process for the synthesis of acyclovir(Ia) by condensation of diacetyl guanine (DAG Va) with 2-oxa-1,4-butanediol diacetate (OBDDA, VIIa) in DMSO in presence of an acid catalyst to get a mixture of N-9/N-7 isomer (66:26). The former is isolated by column chromatography and deacetylated with methanolic ammonia to give acyclovir. Overall yield of acyclovir from guanine is 42%
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05821367 |
| 출처 데이터셋 | uspto-grants-1998_10 |
| ORD ID | ord-5825b520528642f6bbfe1b0fcb252da6 |
| 출처 메모 | uspto-grants-1998_10 |