Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethylformamide → 4-Formyl-2-nitrobenzonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Ethyl Acetate | HCID 8857 | — |
| 반응물 | 4-Bromo-3-nitrobenzaldehyde | HCID 808792 | — |
| 생성물 | 4-Formyl-2-nitrobenzonitrile | HCID 22117815 | 56.1% |
반응 단계
A mixture of 4-bromo-3-nitrobenzaldehyde (1 g, 4.35 mmol) in dimethylformamide (10 mL) was added cuprous cyanide (584.8 mg, 6.53 mmol). The resultant solution was stirred at 160° C. for 5 hours. After cooling, a standard aqueous/EtOAc workup was followed. Purified by silica gel column chromatography to give product (430 mg, yield 56.1%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08741915B2 |
| 출처 데이터셋 | uspto-grants-2014_06 |
| ORD ID | ord-e07eb1dbf2fb4ad7a2790904e0842bc3 |
| 출처 메모 | uspto-grants-2014_06 |