참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Diethyl (ethoxymethylene)malonate | HCID 6871 | — |
| 반응물 | 3-Aminocyclohex-2-en-1-one | HCID 78892 | — |
| 생성물 | diethyl N-(3-oxo-1-cyclohexen-1-yl)-aminomethylenemalonate | HCID 12877078 | 90% |
반응 단계
A mixture of 3-amino-cyclohex-2-enone (3.3 g, 29.7 mmol) and diethyl 2-(ethoxymethylene)malonate (6.7 g, 31.2 mmol) was stirred at 130° C. for 4 h. The reaction mixture was concentrated under reduced pressure and the resulting oil was purified by column chromatography (silica gel, ethyl acetate) to give 2-[(3-oxo-cyclohex-1-enylamino)-methylene]-malonic acid diethyl ester (7.5 g, 90%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08741925B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_06 |
|---|
| ORD ID | ord-f834384df36a40938616eb219eee5085 |
|---|
| 출처 메모 | uspto-grants-2014_06 |
|---|
