참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | Diethyl Ether | HCID 3283 | — |
| 반응물 | 1-Chloroethyl chloroformate | HCID 521305 | — |
| 반응물 | 1-[4-(1-Benzhydryl-azetidin-3-yl)-piperazin-1-yl]-2,2,2-trifluoro-ethanone | HCID 59625975 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | HCID 59625678 | HCID 59625678 | — |
반응 단계
To a solution of compound 1f (2.11 g, 5.23 mmol) in CH2Cl2 (60 mL) was added 1-chloroethyl chloroformate (2.0 mL, 18.35 mmol) at 0° C. under N2. The mixture was stirred at 0° C. for 90 min and then MeOH (4 mL) was added. The mixture was refluxed for 1 h. Upon cooling, Et2O (50 mL) was added to the mixture. The resulting solid was collected by filtration and dried. The crude compound 1g was used in the next reaction without further purification. MS m/z (M+H+) 238.1.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08741887B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_06 |
|---|
| ORD ID | ord-5dbb8425e99f49e8b586783942304c7f |
|---|
| 출처 메모 | uspto-grants-2014_06 |
|---|
