Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 40177생성일: 2026년 10월 24일
Potassium Carbonate → 4-((6-(3-Fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methoxy)-7-methoxyquinoline
https://huagongshe.com/ko/reaction/40177
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 3-Fluorophenylboronic acid | HCID 2733986 | — |
| 반응물 | 4-((6-Chloro-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methoxy)-7-methoxyquinoline | HCID 25066992 | — |
| 촉매 | HCID 178418807 | HCID 178418807 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 4-((6-(3-Fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methoxy)-7-methoxyquinoline | HCID 24864823 | 44.2% |
반응 단계
3-fluorophenylboronic acid (0.092 g, 0.66 mmol) was added to a suspension of 4-((6-chloro-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methoxy)-7-methoxyquinoline (0.150 g, 0.44 mmol) in 2.5 mL dimethylformamide, followed by the addition of potassium carbonate (0.18 g, 1.3 mmol) in 0.6 mL water. PdCl2(dppf)-CH2Cl2 adduct (0.018 g, 0.022 mmol) was added and the flask was purged with argon, sealed and heated at 80° C. for four hours. Purification by MPLC (eluted with 5 then 10% MeOH in CH2Cl2) afforded the product as an off-white solid (78 mg, 44%). (ESI, pos. ion) m/z: 402.1 (M+H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08524900B2 |
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| 출처 데이터셋 | uspto-grants-2013_09 |
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| ORD ID | ord-67a6ae8489094008958c3a4635469c13 |
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| 출처 메모 | uspto-grants-2013_09 |
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