Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
p-Toluenesulfonic acid monohydrate → 7-Methoxy-4-(2-(6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)ethyl)quinoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | p-Toluenesulfonic acid monohydrate | HCID 521998 | — |
| 반응물 | 3-Hydrazinyl-6-phenylpyridazine | HCID 6409842 | — |
| 반응물 | Ethyl 3-(7-methoxyquinolin-4-yl)propanoate | HCID 67503802 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 생성물 | 7-Methoxy-4-(2-(6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)ethyl)quinoline | HCID 25066988 | — |
반응 단계
Ethyl 3-(7-methoxyquinolin-4-yl)propanoate (156 mg, 0.60 mmol) was combined with 1-(6-phenylpyridazin-3-yl)hydrazine (115 mg, 0.62 mmol) and pTsOH.H2O(140 mg, 0.72 mmol). The mixture was microwaved at 150° C. for 60 minutes. The residue was taken up in DMSO and purified by HPLC and neutralized to yield the desired product as an off-white solid. (ESI, pos. ion) m/z: 382.1 (M+H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08524900B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-31f20ad462494b188d876dc5a7c25daa |
| 출처 메모 | uspto-grants-2013_09 |