참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | 2-Bromo-1-(quinolin-6-yl)ethan-1-one | HCID 71699692 | — |
| 반응물 | HCID 178484245 | HCID 178484245 | — |
| 생성물 | (6-Chloroimidazo[1,2-b]pyridazin-3-yl)(quinolin-6-yl)methanone | HCID 86630275 | 61.4% |
반응 단계
A 100 mL RB flask was charged with 2-bromo-1-(quinolin-6-yl)ethanone (0.7011 g, 2.80 mmol), (E)-N′-(6-chloropyridazin-3-yl)-N,N-dimethylformamidine (0.518 g, 2.80 mmol), and DMF (10.0 ml, 129 mmol), equipped with a reflux condenser, then heated at 105° C. for 3 hours. The reaction mixture was concentrated, then triturated with MeOH to yield (6-chloroimidazo[1,2-b]pyridazin-3-yl)(quinolin-6-yl)methanone (0.530 g, 1.72 mmol, 61%) as a brown solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08524900B2 |
|---|
| 출처 데이터셋 | uspto-grants-2013_09 |
|---|
| ORD ID | ord-8fc8e95f1cf14139b7f08442945ff403 |
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| 출처 메모 | uspto-grants-2013_09 |
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