Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → (6-Phenylimidazo[1,2-b]pyridazin-3-yl)(quinolin-6-yl)methanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Cesium carbonate | HCID 10796 | — |
| 반응물 | 1,4-Dioxane | HCID 31275 | — |
| 반응물 | Phenylboronic Acid | HCID 66827 | — |
| 반응물 | (6-Chloroimidazo[1,2-b]pyridazin-3-yl)(quinolin-6-yl)methanone | HCID 86630275 | — |
| 촉매 | HCID 178418807 | HCID 178418807 | — |
| 생성물 | (6-Phenylimidazo[1,2-b]pyridazin-3-yl)(quinolin-6-yl)methanone | HCID 67502844 | — |
반응 단계
A 48 mL sealed tube was charged with (6-chloroimidazo[1,2-b]pyridazin-3-yl)(quinolin-6-yl)methanone (0.530 g, 1.72 mmol), phenylboronic acid (0.314 g, 2.58 mmol), cesium carbonate (1.68 g, 5.15 mmol), PdCl2(dppf)-CH2Cl2 adduct (0.0701 g, 0.0858 mmol), 1,4-dioxane (6.31 ml, 73.8 mmol), and water (1.11 ml, 61.8 mmol), flushed with argon, sealed, then placed in an 80° C. oil bath for 8 hours. The mixture was concentrated then triturated with water, followed by MeOH/DCM to give (6-phenylimidazo[1,2-b]pyridazin-3-yl)(quinolin-6-yl)methanone as a reddish brown solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08524900B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-b8134f6526e44278b383ec473be44edb |
| 출처 메모 | uspto-grants-2013_09 |