Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethylacetate heptane → 6-chloro-N-methyl-4-o-tolylpyridazin-3-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethylacetate heptane | HCID 21899848 | — |
| 반응물 | 6-Chloro-4-o-tolylpyridazin-3-ylamine | HCID 86698477 | — |
| 생성물 | 6-chloro-N-methyl-4-o-tolylpyridazin-3-amine | HCID 86698476 | 17% |
반응 단계
The title compound was prepared in analogy to example 1, intermediate a, from 6-chloro-4-o-tolyl-pyridazin-3-ylamine and using a gradient of n-heptane:ethyl acetate (100:0 to 0:70) eluant for the chromatographic purification. A second purification step on a 20 g column using an MPLC (Flashmaster) system (gradient of n-heptane:ethyl acetate (100:0 to 40:60)) furnished the title compound as a colorless solid (17%). MS (ESI+): m/z=234.080 ([M+H]+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08748434B2 |
| 출처 데이터셋 | uspto-grants-2014_06 |
| ORD ID | ord-10f9c93005484fd3b931f020b563f171 |
| 출처 메모 | uspto-grants-2014_06 |