참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Azobisisobutyronitrile | HCID 6547 | — |
| 반응물 | N-bromobutanimide | HCID 67184 | — |
| 반응물 | Methyl 4-methyl-4'-nitrobiphenyl-3-carboxylate | HCID 67307694 | — |
| 용매 | Carbon Tetrachloride | HCID 5943 | — |
| 생성물 | Methyl 4-(bromomethyl)-4'-nitrobiphenyl-3-carboxylate | HCID 67306641 | — |
반응 단계
The compound of example 3 (5.7 g, 0.021 mol) was dissolved in carbon tetrachloride (125 mL). AIBN (350 mg) and NBS (4.1 g, 0.0231 mol) were added and the reaction mixture was refluxed at 80° C. After completion of the reaction, the reaction mixture was cooled to room temperature and filtered through celite. The filtrate was concentrated to obtain a crude material containing 85% mono bromo and 10% dibromo product and 5% starting material. The crude was used directly without purification for the preparation of the compound of example 5.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08748426B2 |
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| 출처 데이터셋 | uspto-grants-2014_06 |
|---|
| ORD ID | ord-7566dc0364ba4d0e8bd6b284ae59ec52 |
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| 출처 메모 | uspto-grants-2014_06 |
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