Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Aminopyridine → 2-Pyridyl-2-quinolylamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Aminopyridine | HCID 10439 | — |
| 반응물 | 2-Bromoquinoline | HCID 2762756 | — |
| 반응물 | HCID 178418922 | HCID 178418922 | — |
| 촉매 | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| 용매 | Toluene | HCID 1140 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 2-Pyridyl-2-quinolylamine | HCID 5340112 | 45% |
반응 단계
2-Bromoquinoline, I (500 mg, 2.40 mmol), 2-aminopyridine (249 mg, 2.64 mmol), tBuOK (404 mg, 3.60 mmol), (±)-BINAP (6 mg, 0.01 mmol) and Pd2(dba)3 (5.5 mg, 0.006 mmol) were stirred in toluene (10 mL) at 90° C. under Ar(g) for 21 h. The reaction mixture was then diluted with CH2Cl2 (10 mL) and silica was added, followed by the removal of the solvent under reduced pressure. The resulting dry load material was purified by silica gel column chromatography eluting with CH2Cl2/MeOH (100:1 then 100:2) to furnish II as a colourless oil (344 mg, 45%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08748458B2 |
| 출처 데이터셋 | uspto-grants-2014_06 |
| ORD ID | ord-b01f6dbe9a5740c582c3a8b9464be9af |
| 출처 메모 | uspto-grants-2014_06 |