Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Aminopyridine → HCID 58545058, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Aminopyridine | HCID 10439 | — |
| 반응물 | 2-Bromo-4-phenylpyridine | HCID 104700 | — |
| 반응물 | Potassium tert-butoxide | HCID 23665647 | — |
| 촉매 | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| 용매 | Toluene | HCID 1140 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | HCID 58545058 | HCID 58545058 | 62.2% |
반응 단계
2-Bromo-4-phenylpyridine (280 mg, 1.19 mmol), 2-aminopyridine (124 mg, 1.31 mmol), potassium tert-butoxide (201 mg, 1.79 mmol), (±)-BINAP (3 mg, 0.05 mmol) and Pd2(dba)3 (2.7 mg, 0.03 mmol) were stirred in toluene (2.5 mL) at 90° C. under Ar(g). After 17 h stirring, the reaction mixture was diluted with CH2Cl2 (2.5 mL) and silica was added. The solvent was removed under reduced pressure and the resulting dry loaded material purified by silica gel column chromatography, eluting with CH2Cl2/MeOH (100:2), to furnish I as a yellow solid (183 mg, 62%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08748458B2 |
| 출처 데이터셋 | uspto-grants-2014_06 |
| ORD ID | ord-12d4c056b99b495e824f039e45e5457c |
| 출처 메모 | uspto-grants-2014_06 |