Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 404349생성일: 2026년 10월 24일
Potassium Carbonate → Methyl 3-(5,5-dimethylcyclopent-1-enyl)-4-(5-fluoro-2-methoxypyridin-4-yl)benzoate
https://huagongshe.com/ko/reaction/404349
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | (5-Fluoro-2-methoxypyridin-4-yl)boronic acid | HCID 44754837 | — |
| 반응물 | Methyl 3-(5,5-dimethylcyclopent-1-enyl)-4-(trifluoromethylsulfonyloxy)benzoate | HCID 57467618 | — |
| 촉매 | HCID 178418397 | HCID 178418397 | — |
| 생성물 | Methyl 3-(5,5-dimethylcyclopent-1-enyl)-4-(5-fluoro-2-methoxypyridin-4-yl)benzoate | HCID 57467617 | — |
반응 단계
To a flask with methyl 3-(5,5-dimethylcyclopent-1-enyl)-4-(trifluoromethylsulfonyloxy)benzoate T3.5 (404 mg, 1068 μmol) was added Pd(PPh3)4 (123 mg, 107 μmol), potassium carbonate (443 mg, 3203 μmol), 5-fluoro-2-methoxypyridin-4-ylboronic acid T19.1 (456 mg, 2669 μmol, commercially available from Asymchem). The mixture was then degassed, and DMF (3 mL) was added. The reaction was stirred overnight at 87° C. and worked up with EtOAc and water. Silica gel chromatography (0-50% EtOAc/Hexanes) afforded methyl 3-(5,5-dimethylcyclopent-1-enyl)-4-(5-fluoro-2-methoxypyridin-4-yl)benzoate T19.2 (295 mg. 78%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08748462B2 |
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| 출처 데이터셋 | uspto-grants-2014_06 |
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| ORD ID | ord-c5fcfd3eb8b547d9b403a1c90a81e808 |
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| 출처 메모 | uspto-grants-2014_06 |
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