참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 2-Bromo-6-fluoropyridine | HCID 639438 | — |
| 반응물 | (2,2-Difluorocyclopropyl)methanol | HCID 2761401 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 2-Bromo-6-(2,2-difluoro-cyclopropylmethoxy)-pyridine | HCID 86689014 | — |
반응 단계
To 307 mg (2.84 mmol) (2,2-difluorocyclopropyl)methanol in 1,4-dioxane (10 mL) is added 69 mg (2.84 mmol) sodium hydride and 500 mg (2.84 mmol) 2-bromo-6-fluoropyridine. The mixture is stirred for 2 h at 90° C. Water and DMF are added and the mixture is filtered and concentrated in vacuo. The residue is purified by HPLC (C18 RP Sunfire, acetonitrile/water (+0.1% TFA)) to yield the desired product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08530461B2 |
|---|
| 출처 데이터셋 | uspto-grants-2013_09 |
|---|
| ORD ID | ord-8d611a51858c41169343e7666344cf94 |
|---|
| 출처 메모 | uspto-grants-2013_09 |
|---|
