Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → Methyl 5-(5-chloro-2-methylphenyl)picolinate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | (5-Chloro-2-methylphenyl)boronic acid | HCID 2773336 | — |
| 반응물 | Methyl 5-bromopyridine-2-carboxylate | HCID 7016458 | — |
| 촉매 | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | Methyl 5-(5-chloro-2-methylphenyl)picolinate | HCID 71060066 | — |
반응 단계
Methyl 5-bromopicolinate (5.0 g, 23.1 mmol), (5-chloro-2-methylphenyl)boronic acid (4.5 g, 26.6 mmol), Pd(dppf)Cl2 (1.9 g, 2.3 mmol), and K2CO3 (6.4 g, 46.3 mmol) were dissolved in 1,4-dioxane (100 mL) and water (25 mL) and the resulting mixture was heated to 80° C. After 16 h the resulting mixture was cooled to room temperature, diluted with EtOAc, washed with water and brine, dried (Na2SO4), and dry packed onto silica gel. Column chromatography yielded the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08748624B2 |
| 출처 데이터셋 | uspto-grants-2014_06 |
| ORD ID | ord-7b9e4725b0864c9fa9e388386c7b2497 |
| 출처 메모 | uspto-grants-2014_06 |