Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzene → Methyl 5-(2-(bromomethyl)-5-chlorophenyl)picolinate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzene | HCID 241 | — |
| 반응물 | Benzoyl Peroxide | HCID 7187 | — |
| 반응물 | N-bromobutanimide | HCID 67184 | — |
| 반응물 | Methyl 5-(5-chloro-2-methylphenyl)picolinate | HCID 71060066 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | Methyl 5-(2-(bromomethyl)-5-chlorophenyl)picolinate | HCID 86674247 | — |
반응 단계
Solid benzoyl peroxide (496 mg, 2.0 mmol) was added to a benzene solution (50 mL) of methyl 5-(5-chloro-2-methylphenyl)picolinate (3.6 g, 13.6 mmol) and NBS (2.7 g, 15.0 mmol) and the resulting mixture was refluxed. After 16 h the resulting mixture was cooled, diluted with EtOAc, washed with water and brine, dried (Na2SO4), and dry packed onto silica gel. Column chromatography yielded the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08748624B2 |
| 출처 데이터셋 | uspto-grants-2014_06 |
| ORD ID | ord-57635edebc2548bf9ce2ecd6a317cc89 |
| 출처 메모 | uspto-grants-2014_06 |