Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 405180생성일: 2026년 10월 24일
4-Amino-4'-chlorodiphenyl → Ethyl 3-(5-(2-(((4'-chloro-[1,1'-biphenyl]-4-yl)amino)methyl)-6-(trifluoromethyl)phenyl)picolinamido)propanoate
https://huagongshe.com/ko/reaction/405180
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 4-Amino-4'-chlorodiphenyl | HCID 8675 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Sodium triacetoxyborohydride | HCID 5049666 | — |
| 반응물 | Ethyl 3-(5-(2-formyl-6-(trifluoromethyl)phenyl)picolinamido)propanoate | HCID 86674256 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | Ethyl 3-(5-(2-(((4'-chloro-[1,1'-biphenyl]-4-yl)amino)methyl)-6-(trifluoromethyl)phenyl)picolinamido)propanoate | HCID 71059902 | — |
반응 단계
Solid NaBH(OAc)3 (68 mg, 0.32 mmol) was added to a DCM solution (0.4 mL) of ethyl 3-(5-(2-formyl-6-(trifluoromethyl)phenyl)picolinamido)propanoate (50.8 mg, 0.13 mmol) and 4′-chloro-[1,1′-biphenyl]-4-amine (28.9 mg, 0.14 mmol), and AcOH (0.07 mL) and the resulting mixture was warmed to 40° C. After 45 min 5M aqueous K2CO3 was added and the resulting mixture was extracted with DCM. The combined organics were dried (Na2SO4), concentrated and purified via column chromatography to yield the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08748624B2 |
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| 출처 데이터셋 | uspto-grants-2014_06 |
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| ORD ID | ord-dcdfb6295403412cacfbe8696e3861ee |
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| 출처 메모 | uspto-grants-2014_06 |
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