Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetonitrile → 1-Chloro-3-(methoxymethoxy)-5-(trifluoromethyl)benzene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetonitrile | HCID 6342 | — |
| 반응물 | Chloromethyl Methyl Ether | HCID 7864 | — |
| 반응물 | Cesium carbonate | HCID 10796 | — |
| 반응물 | 3-Chloro-5-hydroxybenzotrifluoride | HCID 3852718 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | 1-Chloro-3-(methoxymethoxy)-5-(trifluoromethyl)benzene | HCID 86674286 | — |
반응 단계
Neat chloro(methoxy)methane (1.8 mL, 23.8 mmol) was added to a MeCN solution (20 mL) of 3-chloro-5-(trifluoromethyl)phenol (3.6 g, 18.3 mmol) and Cs2CO3 and the resulting mixture was stirred at room temperature. After 5 h the resulting mixture was diluted with diethyl ether, filtered and concentrated. The resulting material was filtered through a short pad of silica gel, followed by concentration to yield 1-chloro-3-(methoxymethoxy)-5-(trifluoromethyl)benzene.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08748624B2 |
| 출처 데이터셋 | uspto-grants-2014_06 |
| ORD ID | ord-177aa0b162824e86a5fb13a3dd1817a8 |
| 출처 메모 | uspto-grants-2014_06 |