Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Aminophenol → 4-amino-5-bromo-N2-(3-hydroxyphenyl)-2-pyrimidineamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Aminophenol | HCID 11568 | — |
| 반응물 | 4-Amino-5-bromo-2-chloropyrimidine | HCID 2763293 | — |
| 생성물 | 4-amino-5-bromo-N2-(3-hydroxyphenyl)-2-pyrimidineamine | HCID 22060476 | — |
반응 단계
In like manner to the preparation of N4-(3,4-ethylenedioxyphenyl)-5-fluoro-N2-(3-hydroxyphenyl)-4-pyrimidinediamine, 4-amino-5-bromo-2-chloropyrimidine and 3-aminophenol were reacted to give 4-amino-5-bromo-N2-(3-hydroxyphenyl)-2-pyrimidineamine. 1H NMR (DMSO-d6): δ 10.33 (br s, 1H), 8.27 (s, 1H), 7.14-6.06 (m, 2H), 7.01 (d, 1H, J=1.7 Hz), 6.54 (td, 1H, J=1.7 Hz and 7.0 Hz).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08748597B2 |
| 출처 데이터셋 | uspto-grants-2014_06 |
| ORD ID | ord-9f8121e2e20d478ebb6fc9e70a779716 |
| 출처 메모 | uspto-grants-2014_06 |