참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Acetonitrile | HCID 6342 | — |
| 반응물 | Cyclobutylamine | HCID 75645 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 5-Bromo-2-chloropyrimidine | HCID 606665 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 5-bromo-N-cyclobutylpyrimidin-2-amine | HCID 45158687 | — |
반응 단계
In a sealed tube 2.00 g (10.3 mmol) 5-bromo-2-chloropyrimidine, 1.15 mL (13.4 mmol) cyclobutylamin and 2.70 mL (15.5 mmol) DIPEA are added to 12 mL ACN. The reaction mixture is stirred at 50° C. over night, then diluted with EtOAc and washed with water (2×). The org. phase is dried with MgSO4 and the solvent is removed in vacuo.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08530460B2 |
|---|
| 출처 데이터셋 | uspto-grants-2013_09 |
|---|
| ORD ID | ord-2a3a2743c1e9484fb35ba6c301538793 |
|---|
| 출처 메모 | uspto-grants-2013_09 |
|---|
