Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 40633생성일: 2026년 10월 24일
Diisopropylethylamine → (S)-1-(6-Methyl-pyridin-3-yloxy)-3-(-(Z)-(1S,6S)-9-naphthalen-2-yl-7,9-diaza-bicyclo[4.2.2]dec-3-en-7-yl)-propan-2-ol
https://huagongshe.com/ko/reaction/40633
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | Z-(1S,6S)-7-naphthalen-2-yl-7,9-diaza-bicyclo[4.2.2]dec-3-ene | HCID 59686818 | — |
| 반응물 | (S)-2-Methyl-5-oxiranylmethoxy-pyridine | HCID 59686824 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | (S)-1-(6-Methyl-pyridin-3-yloxy)-3-(-(Z)-(1S,6S)-9-naphthalen-2-yl-7,9-diaza-bicyclo[4.2.2]dec-3-en-7-yl)-propan-2-ol | HCID 59686804 | — |
반응 단계
(S)-2-Methyl-5-oxiranylmethoxy-pyridine (13 mg, 0.077 mmol) and Z-(1S,6S)-7-naphthalen-2-yl-7,9-diaza-bicyclo[4.2.2]dec-3-ene (20 mg, 0.189 mmol) were placed in a μW tube with ethanol (3 ml), DIPEA (15 μL, 0.086 mmol) and heated to 95° C. for 900 sec. The solvent was removed and the residue was purified via silica chromatography (30% Ethyl acetate/heptane) to yield the title compound as a residue.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08530475B2 |
|---|
| 출처 데이터셋 | uspto-grants-2013_09 |
|---|
| ORD ID | ord-5d40740e23a44ef7bd32cf080e50788b |
|---|
| 출처 메모 | uspto-grants-2013_09 |
|---|
