Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl morpholine oxide → 3-Chloro-1-benzothiophene-2-carbaldehyde
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl morpholine oxide | HCID 82029 | — |
| 반응물 | (3-Chloro-1-benzothien-2-yl)methanol | HCID 821965 | — |
| 촉매 | HCID 178419074 | HCID 178419074 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 3-Chloro-1-benzothiophene-2-carbaldehyde | HCID 818121 | 84.7% |
반응 단계
A solution of alcohol 12 (4.32 g, 21.6 mmol) in 40 mL of CH2Cl2 was treated with 4A molecular sieves, NMO (3.81 g, 32.5 mmol), and TPAP (381 mg, 1.08 mmol). The reaction was stirred for 10 min. and then was evaporated to dryness. Purification by flash chromatography on silica gel (2% ethyl acetate/hexane) gave 3.52 g (18.3 mmol, 84%) of the aldehyde (13).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08754122B2 |
| 출처 데이터셋 | uspto-grants-2014_06 |
| ORD ID | ord-1a7ba306a4944da791246b5d6332cddc |
| 출처 메모 | uspto-grants-2014_06 |