Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Praziquantel → Praziquanamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Praziquantel | HCID 4891 | — |
| 반응물 | 2-((2,2-Dimethoxyethyl)amino)-N-(2-phenylethyl)acetamide | HCID 10924680 | — |
| 생성물 | Praziquanamine | HCID 6453168 | — |
반응 단계
Further embodiments disclosed herein provide a process for the preparation of Praziquantel of formula I by cyclisation of 2-[(2,2-dimethoxyethyl)amino]-N-(2-phenylethyl)acetamide using an acid in the presence of a solvent to obtain 4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinoline; and acylation of 4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinoline with cyclohexanoylchloride in presence of a base and a solvent to obtain Praziquantel.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08754215B2 |
| 출처 데이터셋 | uspto-grants-2014_06 |
| ORD ID | ord-5b292083e3c441d79e3c3f9a7a28c18c |
| 출처 메모 | uspto-grants-2014_06 |