Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 40729생성일: 2026년 10월 23일
2-Chloro-4-methoxypyrimidine → 4-methoxy-N-(4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)pyrimidin-2-amine
https://huagongshe.com/ko/reaction/40729
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 2-Chloro-4-methoxypyrimidine | HCID 588935 | — |
| 반응물 | 4-(3-Methyl-1H-1,2,4-triazol-1-yl)aniline | HCID 44627476 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 용매 | 1-Ethoxyethanol | HCID 10129898 | — |
| 생성물 | 4-methoxy-N-(4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)pyrimidin-2-amine | HCID 59588178 | — |
반응 단계
To a solution 2-chloro-4-methoxypyrimidine (2 g, 13.8 mmol) in ethoxyethanol (50 mL) was added 4-(3-methyl-1H-1,2,4-triazol-1-yl)aniline (1.7 g, 10.6 mmol). The reaction was warmed to 75° C. for 16 h, cooled, and diluted with water and EtOAc. The layers were separated, and the aqueous layer was extracted with EtOAc (4×). The combined organics were dried (MgSO4), and concentrated to give a near colorless solid which was homogeneous by analytical HPLC analysis and was used without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08530480B2 |
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| 출처 데이터셋 | uspto-grants-2013_09 |
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| ORD ID | ord-65f397ec3e8d46fcb30e760fe36cae26 |
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| 출처 메모 | uspto-grants-2013_09 |
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