3,4-Difluorophenyl isocyanate → 1-(3,4-Difluoro-phenyl)-3-[3-(4-fluoro-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-urea

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3-(4-Fluoro-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenylamine was treated with 3,4-difluorophenylisocyanate, in a similar manner as described in Example 1.69, providing 27 mg (63% yield) of Compound 32: LCMS m/z (%)=377 (M+H, 100). 1H NMR (400 MHz, acetone-d6) δ: 8.28 (s, 1H), 8.12 (s, 1H), 7.74 (ddd, J1=13.5 Hz, J2=7.3 Hz, J3=2.5 Hz, 1H), 7.63 (ddd, J1=8.8 Hz, J2=2.8 Hz, 1H), 7.47 (d, J=2.8 Hz, 1H), 7.38 (d, JH,F=4.4 Hz, 1H), 7.16 (m, 3H), 3.84 (s, 3H), 3.65 (s, 3H). 19F NMR (376 MHz, acetone-d6) δ: −138.89 (m, 1F), −148.38 (m, 1F), −177.40 (d, JH,F=5.3 Hz, 1F).

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