Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 407922생성일: 2026년 10월 24일
Sodium Carbonate → (S)-tert-butyl 3-(2,5-difluoro-4-(methylsulfonyl)phenylamino)-2-oxo-1,4'-bipiperidine-1'-carboxylate
https://huagongshe.com/ko/reaction/407922
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | 1,2,4-Trifluoro-5-(methylsulfonyl)benzene | HCID 46739396 | — |
| 반응물 | (S)-tert-butyl 3-amino-2-oxo-1,4'-bipiperidine-1'-carboxylate | HCID 66802275 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | (S)-tert-butyl 3-(2,5-difluoro-4-(methylsulfonyl)phenylamino)-2-oxo-1,4'-bipiperidine-1'-carboxylate | HCID 67470435 | 72.3% |
반응 단계
(S)-tert-butyl 3-amino-2-oxo-1,4′-bipiperidine-1′-carboxylate (4.0 g, 13 mmol), 1,2,4-trifluoro-5-(methylsulfonyl)benzene (Preparation C, 4.2 g, 20 mmol) and Na2CO3 (2.9 g, 27 mmol) were dissolved in DMF (30 mL) and heated at 130° C. overnight. The reaction was concentrated and purified over silica gel (25-75% EtOAc in hexanes) to afford (S)-tert-butyl 3-(2,5-difluoro-4-(methylsulfonyl)phenylamino)-2-oxo-1,4′-bipiperidine-1′-carboxylate (4.6 g, 9.4 mmol, 70% yield) as yellow solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08754226B2 |
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| 출처 데이터셋 | uspto-grants-2014_06 |
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| ORD ID | ord-95ac0d79b0024d8f8fdbe390394d4565 |
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| 출처 메모 | uspto-grants-2014_06 |
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