Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
D-Lactic Acid → HCID 178462369, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | D-Lactic Acid | HCID 61503 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| 반응물 | HCID 178462199 | HCID 178462199 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | HCID 178462369 | HCID 178462369 | 41% |
반응 단계
Trans-tert-butyl (R)-1-(4-aminocyclohexyl)ethylcarbamate (125 mg, 0.52 mmol) was dissolved in DMF (3 mL). D-Lactic Acid (49.52 mg, 0.52 mmol), diisopropylethylamine (166.6 mg, 224.5 μL, 1.29 mmol) and TBTU (165.6 mg, 0.5158 mmol) were successively added. The reaction mixture was allowed to stir at ambient temperature for 3 hours. The crude mixture was partitioned between ethyl acetate and brine. The organic extracts were dried over magnesium sulfate, filtered and concentrated in vacuo. The residue was purified on silica gel by column chromatography (ISCO Companion, 12 g column, 0-10% MeOH/DCM) to afford the title compound (66.1 mg, 41% yield).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08530489B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-7f8733391c0a42b8b5a5e55392f268ff |
| 출처 메모 | uspto-grants-2013_09 |