Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 40876생성일: 2026년 10월 23일
4-Chloro-1H-pyrrolo[2,3-b]pyridine → 4-(4-bromo-3-methyl-1H-pyrazol-1-yl)-1H-pyrrolo[2,3-b]pyridine
https://huagongshe.com/ko/reaction/40876
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 4-Chloro-1H-pyrrolo[2,3-b]pyridine | HCID 11389493 | — |
| 반응물 | HCID 178434489 | HCID 178434489 | — |
| 생성물 | 4-(4-bromo-3-methyl-1H-pyrazol-1-yl)-1H-pyrrolo[2,3-b]pyridine | HCID 17754465 | 87.5% |
반응 단계
A mixture of 4-chloro-1H-pyrrolo[2,3-b]pyridine (0.050 g, 0.00033 mol) and 4-bromo-3-methyl-1H-pyrazole (0.10 g, 0.00066 mol) was heated at 130° C. overnight. The reaction mixture then was subjected to column chromatography (eluting with 5% MeOH/DCM, 0.5% NH4OH, on silica gel) to give 80 mg pale yellow solid which was triturated with MeOH (1.5 mL) to yield the product as a pale yellow solid (44 mg, 44% yield).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08530485B2 |
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| 출처 데이터셋 | uspto-grants-2013_09 |
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| ORD ID | ord-0655278322ac48cd8d34c7d13d48d0cc |
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| 출처 메모 | uspto-grants-2013_09 |
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