Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dichloromethane → (2S)-2,3-dihydro-1H-inden-2-yl 2-(chloro(naphthalen-1-yloxy)phosphorylamino)propanoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dichloromethane | HCID 6344 | — |
| 반응물 | p-Toluenesulfonate | HCID 85570 | — |
| 반응물 | 1-Dichlorophosphoryloxynaphthalene | HCID 575631 | — |
| 반응물 | (S)-2,3-dihydro-1H-inden-2-yl 2-aminopropanoate | HCID 66780036 | — |
| 생성물 | (2S)-2,3-dihydro-1H-inden-2-yl 2-(chloro(naphthalen-1-yloxy)phosphorylamino)propanoate | HCID 66779638 | 65% |
반응 단계
Using the general procedure for synthesizing naphthyl (aminoacid ester) phosphorochloridates the tosylate salt of (S)-2,3-dihydro-1H-inden-2-yl 2-aminopropanoate (2.00 g, 5.30 mmol), naphthalen-1-yl phosphorodichloridate (1.38 g, 5.30 mmol) and TEA (1.48 mL, 10.60 mmol) in 30 mL of dry DCM, were combined to give (2S)-2,3-dihydro-1H-inden-2-yl 2-(chloro(naphthalen-1-yloxy)phosphorylamino)propanoate in 65% yield (1.48 g), as a yellow, thick oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08759318B2 |
| 출처 데이터셋 | uspto-grants-2014_06 |
| ORD ID | ord-d86dc1344eae4028b02c44fcf5a28354 |
| 출처 메모 | uspto-grants-2014_06 |