Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dichloromethane → (2S)-propyl 2-(chloro(naphthalen-1-yloxy)phosphorylamino)propanoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dichloromethane | HCID 6344 | — |
| 반응물 | p-Toluenesulfonate | HCID 85570 | — |
| 반응물 | 1-Dichlorophosphoryloxynaphthalene | HCID 575631 | — |
| 반응물 | Propyl (2S)-2-aminopropanoate | HCID 13742990 | — |
| 생성물 | (2S)-propyl 2-(chloro(naphthalen-1-yloxy)phosphorylamino)propanoate | HCID 86662563 | 82% |
반응 단계
Using the general procedure for synthesizing naphthyl (aminoacid ester) phosphorochloridates the tosylate salt of (S)-propyl 2-aminopropanoate (2.00 g, 11.93 mmol), naphth-1-yl phosphorodichloridate (3.11 g, 11.93 mmol) and TEA (3.32 mL, 23.86 mmol) in 30 mL of dry DCM, were combined to give (2S)-propyl 2-(chloro(naphthalen-1-yloxy)phosphorylamino)propanoate in 82% yield (3.50 g), as a clear, yellow, thick oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08759318B2 |
| 출처 데이터셋 | uspto-grants-2014_06 |
| ORD ID | ord-0d2b0f3b14104d6b988b39e944bffe61 |
| 출처 메모 | uspto-grants-2014_06 |