Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dichloromethane → (2S)-isobutyl 2-(chloro(naphthalen-1-yloxy)phosphorylamino)propanoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dichloromethane | HCID 6344 | — |
| 반응물 | p-Toluenesulfonate | HCID 85570 | — |
| 반응물 | 1-Dichlorophosphoryloxynaphthalene | HCID 575631 | — |
| 반응물 | 2-methylpropyl (2S)-2-aminopropanoate | HCID 13743556 | — |
| 생성물 | (2S)-isobutyl 2-(chloro(naphthalen-1-yloxy)phosphorylamino)propanoate | HCID 66778743 | — |
반응 단계
Using the general procedure for synthesizing naphthyl (aminoacid ester) phosphorochloridates, the tosylate salt of (S)-isobutyl 2-aminopropanoate (2.5 g), naphthalen-1-yl phosphorodichloridate (2.06 g), TEA (2.19 mL) and DCM (50 mL) were combined to give (2S)-isobutyl 2-(chloro(naphthalen-1-yloxy)phosphorylamino)propanoate as a crude pale yellow thick oil. The crude compound was taken forward without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08759318B2 |
| 출처 데이터셋 | uspto-grants-2014_06 |
| ORD ID | ord-01f4de3f1ec5446fa281653c52750d37 |
| 출처 메모 | uspto-grants-2014_06 |