Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Borane;tetrahydrofuran → Tert-butyl 3-hydroxy-1-(thiophen-3-yl)propylcarbamate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Borane;tetrahydrofuran | HCID 2723981 | — |
| 반응물 | 3-((tert-Butoxycarbonyl)amino)-3-(thiophen-3-yl)propanoic acid | HCID 2764536 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | Tert-butyl 3-hydroxy-1-(thiophen-3-yl)propylcarbamate | HCID 59161739 | — |
반응 단계
To (±)-2-(tert-butoxycarbonylamino)-2-(thiophen-3-yl)propanoic acid (E4) in THF at 0° C. is added BH3-THF dropwise. The solution is allowed to warm to room temperature and stirred for an additional 2 hours. The solution is cooled to 0° C., quenched with AcOH (10%)/MeOH, and evaporated. Column chromatography (SiO2, EtOAc) gives pure tert-butyl 3-hydroxy-1-(thiophen-3-yl)propylcarbamate (E73A).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08759388B2 |
| 출처 데이터셋 | uspto-grants-2014_06 |
| ORD ID | ord-4bd74dcff9f34820961402aee4bb2610 |
| 출처 메모 | uspto-grants-2014_06 |