Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Cesium carbonate → N-(4-(3-bromopyridin-2-yloxy)phenyl)-1-methyl-1H-benzo[d]imidazol-2-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Cesium carbonate | HCID 10796 | — |
| 반응물 | 3-Bromo-2-chloropyridine | HCID 693324 | — |
| 반응물 | 4-(1-methyl-1H-benzoimidazol-2-ylamino)-phenol | HCID 59327014 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Sodium chloride; water | HCID 57417360 | — |
| 생성물 | N-(4-(3-bromopyridin-2-yloxy)phenyl)-1-methyl-1H-benzo[d]imidazol-2-amine | HCID 59327116 | — |
반응 단계
To a round bottomed flask was added 4-(1-methyl-1H-benzo[d]imidazol-2-ylamino)phenol (1.0058 g, 4.20 mmol), 3-bromo-2-chloropyridine (1.213 g, 6.31 mmol), and cesium carbonate (2.74 g, 8.41 mmol) in DMSO (14.01 mL) at 100° C. to stir. Upon completion, reaction was allowed to cool to room temperature. The reaction mixture was diluted with water (10 mL)/Brine (10 mL) and extracted with DCM (3×15 mL). A precipitate formed during extraction. The solid was filtered to provide N-(4-(3-bromopyridin-2-yloxy)phenyl)-1-methyl-1H-benzo[d]imidazol-2-amine.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08759532B2 |
| 출처 데이터셋 | uspto-grants-2014_06 |
| ORD ID | ord-ae882382efb44cd7820fb9523d4e79c5 |
| 출처 메모 | uspto-grants-2014_06 |