Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-(2-Hydroxyethyl)piperazine → 1-Acetyl-4-(2-hydroxyethyl)piperazine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-(2-Hydroxyethyl)piperazine | HCID 7677 | — |
| 반응물 | Acetic Anhydride | HCID 7918 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 1-Acetyl-4-(2-hydroxyethyl)piperazine | HCID 4739629 | 65% |
반응 단계
A solution of 2-(1-piperazinyl)-1-ethanol (6.5 g, 0.05 mol) in DCM (5 mL) was treated with acetic acid anhydride (5.1 g, 0.05 mol), added dropwise. During addition, the reaction temperature rose from 22 to 60° C. The reaction mixture was evaporated several times with toluene to yield 5.6 g (65%) of the sub-title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06559162B2 |
| 출처 데이터셋 | uspto-grants-2003_05 |
| ORD ID | ord-719de8e84b1941b0afa086c4c952fcc5 |
| 출처 메모 | uspto-grants-2003_05 |