참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Allyl bromide | HCID 7841 | — |
| 반응물 | Ethyl Acetate | HCID 8857 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 2-(Benzyloxy)-5-hydroxybenzaldehyde | HCID 18536192 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 2-Benzyloxy-5-[(2-propenyl)oxy]benzaldehyde | HCID 18536183 | — |
반응 단계
To a solution of the product from Step A (75.4 mmol) in 100 mL of DMF was added potassium carbonate (20.8 g, 150.7 mmol), followed by allyl bromide (11.7 mL, 135 mmol). The reaction was warmed to 60° C. and stirred for one hour. The solution was poured into EtOAc and washed with water, saturated NaHCO3 solution and brine, dried (Na2SO4), filtered, and concentrated in vacuo. The resulting product was purified by silica gel chromatography (20-30% EtOAc/hexane) to provide the titled product, along with unreacted starting material (4.39 g, 26%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06562823B1 |
|---|
| 출처 데이터셋 | uspto-grants-2003_05 |
|---|
| ORD ID | ord-1b40a4cf657d453cb3e06a20ba23ab57 |
|---|
| 출처 메모 | uspto-grants-2003_05 |
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