Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl Benzoate → 3-{4-[3-Biphenyl-2-ylmethyl-1-(4-cyclohexylphenyl)ureidomethyl]benzoylamino}-2(R)-hydroxypropionic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl Benzoate | HCID 7150 | — |
| 반응물 | 1-Biphenyl-2-ylmethanamine | HCID 263366 | — |
| 반응물 | N-chlorocarbamoyl-4-[(4-cyclohexylphenylamino)methyl]benzoic acid methyl ester | HCID 86586062 | — |
| 반응물 | (R)-isoserine ethyl ester hydrochloride | HCID 86586063 | — |
| 생성물 | 3-{4-[3-Biphenyl-2-ylmethyl-1-(4-cyclohexylphenyl)ureidomethyl]benzoylamino}-2(R)-hydroxypropionic acid | HCID 10258106 | — |
반응 단계
This compound was prepared similarly as described in example 35 from N-chlorocarbamoyl-4-[(4-cyclohexylphenylamino)methyl]benzoic acid methyl ester and biphenyl-2-ylmethylamine followed by hydrolysis of the benzoic acid methyl ester, coupling with (R)-isoserine ethyl ester hydrochloride. Hydrolysis afforded the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06562807B2 |
| 출처 데이터셋 | uspto-grants-2003_05 |
| ORD ID | ord-de5d1ad0dcf94b3684155d7172a7e1b6 |
| 출처 메모 | uspto-grants-2003_05 |