Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Piperidine → (R)-3-(4-Formylbenzoylamino)-2-hydroxypropionic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Piperidine | HCID 8082 | — |
| 반응물 | 4-Formylbenzoic acid | HCID 12088 | — |
| 반응물 | Diisopropylcarbodiimide | HCID 12734 | — |
| 반응물 | 1-Hydroxybenzotriazole | HCID 75771 | — |
| 반응물 | (R)-Fmoc-isoserine | HCID 7408673 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 용매 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 생성물 | (R)-3-(4-Formylbenzoylamino)-2-hydroxypropionic acid | HCID 86586064 | — |
반응 단계
To the above resin bound (R)-Fmoc-isoserine was added 500 μL of a 20% solution of piperidine in DMF. Upon shaking for 30 min, the resin was drained and washed with N-methyl-2-pyrrolidinone (6×1 mL). Then 200 μmol 4-formylbenzoic acid (30 mg) and 200 μmol HOBt (31 mg) were dissolved in N-methyl-2-pyrrolidinone (500 μL) and added to the resin followed by 200 μmol diisopropyl carbodiimide (25.2 mg) dissolved in acetonitrile (500 μL). The mixture was shaken for 4 hours at 25° C. followed by filtration and washing of the resin with N-methyl-2-pyrrolidinone (3×1 mL).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06562807B2 |
| 출처 데이터셋 | uspto-grants-2003_05 |
| ORD ID | ord-383780df73b9491b815a3b050be6cceb |
| 출처 메모 | uspto-grants-2003_05 |