Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Phosphorus oxychloride → HCID 178506089, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Phosphorus oxychloride | HCID 24813 | — |
| 반응물 | 5-Trifluoromethyl-1,3-dihydro-benzimidazol-2-one | HCID 11820150 | — |
| 생성물 | HCID 178506089 | HCID 178506089 | — |
반응 단계
Reflux 5-trifluoromethyl-1,3-dihydro-benzimidazol-2-one (17 g; Meanwell et al. (1995) J. Org. Chem. 60(6):1565-1582) for 14 hours in POCl3 (200 mL). Evaporate the solvent in vacuo, then carefully neutralize with saturated NaHCO3, and extract with EtOAc. Dry over Na2SO4, concentrate under vacuum, and purify by flash chromatography (1 :1 hexanes/EtOAc) to obtain 2-chloro-5-trifluoromethyl-1H-benzimidazole.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06566367B2 |
| 출처 데이터셋 | uspto-grants-2003_05 |
| ORD ID | ord-fbeaed5d9688447db1d8c343a4d15b84 |
| 출처 메모 | uspto-grants-2003_05 |