Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3H-spiro(isobenzofuran-1,4'-piperidin)-3-one → HCID 178519033, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3H-spiro(isobenzofuran-1,4'-piperidin)-3-one | HCID 9834255 | — |
| 반응물 | HCID 178527270 | HCID 178527270 | — |
| 용매 | Dimethylacetamide | HCID 31374 | — |
| 생성물 | HCID 178519033 | HCID 178519033 | — |
반응 단계
Stir 2-chloro-5-trifluoromethylsulfonyl-1H-benzimidazole (185 mg) and spiro[isobenzofuran-1,4′-piperidin]-3-one (263 mg) in dimethylacetamide (6 mL) at 195° C. for 1 hour. Cool the mixture and partition between EtOAc and half-saturated NaHCO3, wash several times with water, dry and concentrate in vacuo. Purify the residue by chromatography (1:1 hexanes/EtOAc) to obtain 1′-(5-trifluoromethylsulfonyl-1H-benzimidazol-2-yl)-spiro[isobenzofuran-1,4′-piperidin]-3-one.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06566367B2 |
| 출처 데이터셋 | uspto-grants-2003_05 |
| ORD ID | ord-409f3a4d3f4148a19b872db543aaf871 |
| 출처 메모 | uspto-grants-2003_05 |