Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3H-spiro(isobenzofuran-1,4'-piperidin)-3-one → 1'-(5-(3-methoxyphenyl)-1H-benzimidazol-2-yl)-spiro[isobenzofuran-1,4'-piperidin]-3-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3H-spiro(isobenzofuran-1,4'-piperidin)-3-one | HCID 9834255 | — |
| 반응물 | 2-Chloro-5-(3-methoxyphenyl)benzimidazole | HCID 12071665 | — |
| 용매 | Dimethylacetamide | HCID 31374 | — |
| 생성물 | 1'-(5-(3-methoxyphenyl)-1H-benzimidazol-2-yl)-spiro[isobenzofuran-1,4'-piperidin]-3-one | HCID 178489666 | — |
반응 단계
Stir 2-chloro-5-(3-methoxyphenyl)benzimidazole (185 mg) and spiro[isobenzofuran-1,4′-piperidin]-3-one (263 mg) in dimethylacetamide (6 mL) at 195° C. for 1 hour. Cool the mixture and partition between EtOAc and half-saturated NaHCO3, wash several times with water, dry and concentrate in vacuo. Purify the residue by chromatography (1:1 hexanes/EtOAc) to obtain 1′-(5-(3-methoxyphenyl)-1H-benzimidazol-2-yl)-spiro[isobenzofuran-1,4′-piperidin]-3-one.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06566367B2 |
| 출처 데이터셋 | uspto-grants-2003_05 |
| ORD ID | ord-0745cac6e265473988874d2975053787 |
| 출처 메모 | uspto-grants-2003_05 |