참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Pyrrolidine | HCID 31268 | — |
| 반응물 | Dimethylformamide dimethyl acetal | HCID 78373 | — |
| 반응물 | 2-Methoxy-4-methyl-5-nitropyridine | HCID 243169 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 5-methoxy-1H-pyrrolo(2,3-c)pyridine | HCID 641092 | — |
반응 단계
10.76 g of N,N-dimethylformamide dimethyl acetal and 2.45 ml of pyrrolidine are added, in succession, to a solution of 5 g of the product obtained in Step 1 in 60 ml of dimethylformamide. The mixture obtained is first heated at 100° C. for 8 hours and then at 150° C. for 1 hour. Concentration is carried out under a vacuum of 10−1 mbar and the residue is taken up in 150 ml of tetrahydrofuran. The solution obtained is hydrogenated under a pressure of 10 bars for 4 hours in the presence of 10% Pd/C. After filtration and concentration, the residue is chromatographed over silica (eluant CH2Cl2/EtOH: 95/5) to yield the expected product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06566364B2 |
|---|
| 출처 데이터셋 | uspto-grants-2003_05 |
|---|
| ORD ID | ord-a3061b7900ab4dd4bb7e76ad2c4cb10f |
|---|
| 출처 메모 | uspto-grants-2003_05 |
|---|
