Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Methylglutaric anhydride → (3RS)-3-methyl-5-oxo-5-[4-(2-oxo-2-pyrrolidin-1-ylethyl)piperazin-1-yl]pentanoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Methylglutaric anhydride | HCID 77828 | — |
| 반응물 | 1-((Pyrrolidine-1-carbonyl)methyl)piperazine | HCID 100614 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | (3RS)-3-methyl-5-oxo-5-[4-(2-oxo-2-pyrrolidin-1-ylethyl)piperazin-1-yl]pentanoic acid | HCID 18521560 | 110.7% |
반응 단계
1.6 g of 3-methylglutaric anhydride and then 2.62 g of pyrrolidinocarbonylmethyl-piperazine are added to 10 cm3 of dioxane. After stirring for 8 hours, an additional 320 mg of 3-methylglutaric anhydride are added and then the stirring is continued at 20° C. for 18 hours. The solvent is then evaporated under reduced pressure and then the resulting oil is dried at 45° C. (90 Pa) to give 4.5 g of (3RS)-3-methyl-5-oxo-5-[4-(2-oxo-2-pyrrolidin-1-ylethyl)piperazin-1-yl]pentanoic acid in the form of an orange-colored oil which is used as it is.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06569854B1 |
| 출처 데이터셋 | uspto-grants-2003_05 |
| ORD ID | ord-b05c9376a38d4c43968e121e5ce5d2fe |
| 출처 메모 | uspto-grants-2003_05 |