참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Acetic Acid | HCID 176 | — |
| 반응물 | 3-Hydroxyphthalic anhydride | HCID 96580 | — |
| 반응물 | 2,4-Dimethoxybenzylamine | HCID 597250 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 2-(2,4-Dimethoxy-benzyl)-4-hydroxy-isoindole-1,3-dione | HCID 59263128 | 73% |
반응 단계
A mixture of 3-hydroxyphthalic anhydride (1.24 g, 7.6 mmol), 2,4-dimethoxybenzylamine (1.14 mL, 7.6 mmol) and acetic acid (5 mL) was heated at 80° C. for 24 hours. The mixture was allowed to cool and diluted with water (20 mL). The white solid was collected by filtration, washed well with water and dried to give the title compound (1.73 g, 73%). 1H NMR (DMSO-d6) 11.00 (1H, s), 7.62 (1H, dd), 7.29 (1H, d), 7.21 (1H, d), 6.90 (1H, d), 6.56 (1H, d), 6.43 (1H, dd), 4.59 (2H, s), 3.79 (3H, s), 3.72 (3H, s). MS: [M−H+] 314.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08530469B2 |
|---|
| 출처 데이터셋 | uspto-grants-2013_09 |
|---|
| ORD ID | ord-3204a4b7bfac4724a29b02172a4d9b12 |
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| 출처 메모 | uspto-grants-2013_09 |
|---|
