Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
benzyl 3-(chlorocarbonyl)tetrahydro-1(2H)-pyridinecarboxylate → Benzyl-3-(2-hydroxy-3-(methoxycarbonyl)phenylcarbamoyl)piperidine-1-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | benzyl 3-(chlorocarbonyl)tetrahydro-1(2H)-pyridinecarboxylate | HCID 2776575 | — |
| 반응물 | Methyl 3-amino-2-hydroxybenzoate | HCID 12782444 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | Benzyl-3-(2-hydroxy-3-(methoxycarbonyl)phenylcarbamoyl)piperidine-1-carboxylate | HCID 66621331 | 97% |
반응 단계
Benzyl 3-(chlorocarbonyl)piperidine-1-carboxylate (500 mg, 3 mmol) and methyl 3-amino-2-hydroxybenzoate (1.014 g, 3.6 mmol) were added in anhydrous dichloromethane (20 mL) and the mixture was stirred at room temperature overnight. The mixture was extracted with dichloromethane (100 mL×4) and the organic phase was dried with anhydrous sodium sulfate and evaporated under reduced pressure. 1.2 g benzyl-3-(2-hydroxy-3-(methoxycarbonyl)phenylcarbamoyl)piperidine-1-carboxylate was obtained. Yield: 97%. LC-MS (ESI) m/z: 413 (M+1)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08088760B2 |
| 출처 데이터셋 | uspto-grants-2012_01 |
| ORD ID | ord-3803e9b9c49f4cbc82b19b5be917c2cc |
| 출처 메모 | uspto-grants-2012_01 |